High-Throughput 3D Tumor Spheroid Screening Method for Cancer Drug Discovery Using Celigo Image Cytometry
نویسندگان
چکیده
منابع مشابه
Live Multicellular Tumor Spheroid Models For High-Content Imaging and Screening In Cancer Drug Discovery
The multi cellular tumor spheroid (MCTS) model has been used for decades with proven superiority over monolayer cell culture models at recapitulating in vivo tumor growth. Yet its use in high-throughput drug discovery has been limited, particularly with image based screening, due to practical and technical hurdles. Here we report a significant advance in utilizing live MCTS models for high-cont...
متن کاملCell-Based Assays in High-Throughput Screening for Drug Discovery
Drug screening is a long and costly process confronted with low productivity and challenges in using animals, which limit the discovery of new drugs. To improve drug screening efficacy and minimize animal testing, recent efforts have been dedicated to developing cell-based high throughput screening (HTS) platforms that can provide more relevant in vivo biological information than biochemical as...
متن کاملHigh Throughput Screening for Anti–Trypanosoma cruzi Drug Discovery
The discovery of new therapeutic options against Trypanosoma cruzi, the causative agent of Chagas disease, stands as a fundamental need. Currently, there are only two drugs available to treat this neglected disease, which represents a major public health problem in Latin America. Both available therapies, benznidazole and nifurtimox, have significant toxic side effects and their efficacy agains...
متن کاملBiomimetic 3D Tissue Models for Advanced High-Throughput Drug Screening.
Most current drug screening assays used to identify new drug candidates are 2D cell-based systems, even though such in vitro assays do not adequately re-create the in vivo complexity of 3D tissues. Inadequate representation of the human tissue environment during a preclinical test can result in inaccurate predictions of compound effects on overall tissue functionality. Screening for compound ef...
متن کاملAdd-on for High Throughput Screening in Material Discovery for Organic Electronics: “Tagging” Molecules to Address the Device Considerations
This work reflects the worth of intelligent modeling in controlling the nanostructure morphology in manufacturing organic bulk heterojunction (BHJ) solar cells. It suggests the idea of screening the pool of material design possibilities inspired by machine learning. To fulfill this goal, a set of experimental data on a BHJ solar cell with a donor structure of diketopyrrolopyrrole (DDP) and ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: SLAS TECHNOLOGY: Translating Life Sciences Innovation
سال: 2016
ISSN: 2472-6303,2472-6311
DOI: 10.1177/2211068216652846